Molecular evolution |
Molecular homology: replacement, insertion and deletion. Multiple Alignment. Models of nucleotide and amino acid substitution. Model selection. Phylogenetic methods. Reconstruction of maximum likelihood. Error and phylogenetic confidence. |
Structural biology I |
Visualisation of biological macromolecules. Prediction of 1 D characteristics of proteins: sequences, domains. Three-dimensional structure of proteins. Prediction of 3D structure of proteins: modeling by homology and modeling by threading or design by remote homology. Methods ab initio. Molecular docking: Prediction of protein-substrate and protein-protein interactions. Evaluation of the methods of prediction. |