Subject 2. Drug targets |
Types of drug targets. Drug-target interactions. Nucleic Acids, enzymes and proteins as drug targets. |
Subject 4. Pharmacokinetic and related aspects |
Absorption and transport through biological membranes, the Lipinski rules, bioavailabilty. Metabolism, prodrugs. Excretion. ways of drug administration and pharmaceutical forms. |
Subject 5. Discovery, design and development of drugs |
Strategies for lead discovery, serendipity, systematic screening, rational design. Pharmacomodulation. Patents. preclinical and clinical trials. Chemical development. |
Subject 6. Strategies for drug design |
Molecular modeling, indirect methods (QSAR, pharmacophore design), direct methods (docking). |