2. Elimination Reactions. |
Reactions of elimination. Bimolecular Elimination (E2). Unimolecular Elimination (E1). Base conjugated unimolecular elimination (E1cB). Intramolecular elimination (Ei). Mechanisms. Substitution and elimination competition. Application of elimination reactions in organic synthesis. |
5. Radical reactions. |
Structure, stability and reactivity of radicals. Halogenation of alkanes. Radical addition of HBr to alkenes. Radical halogenation of allylic and benzilic systems. Polymerization of alkenes. |
5. Bifunctional Compounds. |
Reactivity of 1,2-Bifunctional compounds: pinacol rearrangement, benzoinic condensation, acyloin condensation, benzyl acid rearrangement, enolization. Reactions of beta-dicarbonyl compounds: malonic synthesis, acetoacetic ester synthesis, Knoevenagel reaction. Reactions of alpha-beta unsaturated carbonyl compounds: reactions with electrophiles, reactions with nucleophiles, carbanion addition (Michael reaction), Robinson annulation. |