Lesson 2. Reactivity of organic compounds |
Acid-base reactivity of organic compounds. Reaction mechanisms: stepwise reactions. Energetic profile of a reaction. Heterolytic bond cleavage. Ionic reactions. Reaction intermediates: carbanions.
Redox reactivity of organic compounds. Formal states of oxidation. |
Lesson 4. Aromatic substitution reactions |
Structure and general reactivity of aromatic compounds.
General mechanism for the electrophilic aromatic substitution reaction. Reactions with non-carbon electrophiles. Reactions with carbon electrophiles. Electrophilic aromatic substitution reactions in substituted systems: orientation and reactivity. Modulation of the reactivity of aromatic rings.
Nucleophilic aromatic substitution reactions.
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Lesson 6. Reactions of nucleophilic substitution at the carbonyl group |
Structure and general reactivity of carboxylic acids and their derivatives. Relative reactivity of acid derivatives: basicity and electrophilic character.
Non reversible addition-elimination reactions: leaving group.
Reversible addition-elimination reactions: basic catalysis and acid catalysis. Reactions with water and alcohols; reactions with ammonia and amines.
Structure and reactivity of nitriles. Reactions of nitriles. |
Practice 2 |
Electrophilic addition to a double bond. One session. |
Practice 4 |
Reduction of a ketone. One session. |
Practice 6 |
Hydrolysis of an ester. One session. |