Guia docente 2018_19 Facultade de Química

Contents

Topic	Sub-topic
Subject 1. Introduction: general aspects of Pharmaceutical Chemistry	Definitions, aims and scope of the Pharmaceutical Chemistry. Nomeclature of drugs and classification systems. Chemotherapeutic and pharmacodynamic agents
Subject 2. Drug targets	Types of drug targets. Drug-target interactions. Nucleic Acids, enzymes and proteins as drug targets.
Subject 3. Receptors as drug targets	Types of receptors. Agonist, antagonist and inverse agonist drugs. Measure and expression of pharrmacological effect. Drug tolerance and tachyphylaxis
Subject 4. Pharmacokinetic and related aspects	Absorption and transport through biological membranes, the Lipinski rules, bioavailabilty. Metabolism, prodrugs. Excretion. ways of drug administration and pharmaceutical forms.
Subject 5. Discovery, design and development of drugs	Strategies for lead discovery, serendipity, systematic screening, rational design. Pharmacomodulation. Patents. preclinical and clinical trials. Chemical development.
Subject 6. Strategies for drug design	Molecular modeling, indirect methods (QSAR, pharmacophore design), direct methods (docking).
Subject 7. Preparation, analysis and purification of drugs	Production in the pharmaceutical industry. fermentative processes. Drug processing.