Guia docente 2023_24 Facultade de Química

Contents

Topic	Sub-topic
1. Thermodynamics and Kinetics of Organic Reactions	Thermodynamic stability. Chemical kinetics. Coordinate diagrams of reaction. Transition state theory. Arrhenius equation. Reaction rate expressions. Kinetic control and thermodynamic control. Hammond's postulate. Curtin–Hammett principle.
2. Methods for the study of Organic Reactions	Applications of chemical kinetics to the study of the mechanisms of reaction. Kinetic isotope effects. Effect of substituents. Hammett correlations.
3. Acid and base catalysis of organic reactions	Acidity and basicity in organic compounds. Specific acid catalysis. General acid catalysis. Basic catalysis.
4. Frontier Orbitals	Fukui postulate. Klopman-Salem Equation.
5. Reaction Intermediates	Radicals. Carbenes. Carbocations. Carbanions. Structure and stability of these intermediates, generation and reactivity. Reaction intermediates detection. Stereochemistry and reaction mechanisms.
Practice 1. Effect of sterics and electronics on the aldol condensation reaction. Hammett correlation.
Practice 2. Study of the primary isotope effect in the oxidation of 1-phenylethanol