LESSON 2. Reactions of elimination |
Bimolecular elimination reaction (E2). Unimolecular elimination reaction (E1). Competition between substitution and elimination. Application of elimination reactions in organic synthesis. |
LESSON 3. Reactions of nucleophilic addition to the carbonyl group |
Structure and general reactivity of the carbonyl group (aldehydes and ketones). General mechanism of the nucleophilic addition. Addition of oxygenated and sulfur compounds, nitrogenated compounds, hydride, organometallic compounds, cyanide, and acetylides. The reaction of Wittig. |
LESSON 4. Reactions of nucleophilic substitution on the carbonyl group |
Structure and general reactivity of carboxylic acids and derivatives. Preparation and reactivity of acid halides, acid anhydrides, esters, and amides. Structure and reactivity of nitriles. |
LESSON 6. Reactivity of bifunctional carbonyl compounds |
Reactions of beta-dicarbonyl compounds. Reactions of alpha-beta unsaturated carbonyl compounds. Michael reaction. Robinson annulation. |