Guia docente 2024_25 Facultad de Biología

Contents

Topic	Sub-topic
Introduction to Bioinformatics. Unix	Introduction to the Operative systems. Basic commands. File systems. Management of archives and directories. Other commands.
Molecular evolution	Molecular homology: replacement, insertion and deletion. Multiple Alignment. Models of nucleotide and amino acid substitution. Model selection. Phylogenetic methods. Reconstruction of maximum likelihood. Error and phylogenetic confidence.
Genomic analysis	Researches in databases: BLAST. Genome Projects. Structural genomics. Secuencing. Gene prediction. Functional annotation. Comparative genomics.
Structural biology I	Visualisation of biological macromolecules. Prediction of 1 D characteristics of proteins: sequences, domains. Three-dimensional structure of proteins. Prediction of 3D structure of proteins: modeling by homology and modeling by threading or design by remote homology. Methods ab initio. Molecular docking: Prediction of protein-substrate and protein-protein interactions. Evaluation of the methods of prediction.
Structural biology II	Structure of RNA. Prediction of RNA structures. Databases and servers of programs for the analysis of: sequences, structural motifs and functional structures.